Researchers use mussel-derived protein to develop customized underwater bio-adhesive patches

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Customizable underwater bio-adhesive patch, based on muscle adhesive protein, allows adjustable biodegradability and stretchability. Credit: Postec

The field of adhesives is diverse, catering to a wide range of applications from everyday uses such as paper and fabric to specialized uses such as woodworking. In the medical field, adhesives play a vital role in everything from stitching internal wounds to attaching sensors and implanting medical devices. A recent breakthrough in this area has generated considerable excitement: the development of medical adhesives that are not only safe for human use but also adaptable to different organs.

Pohang University of Science and Technology (POSTECH) Professor Heung Jun Cha, Ph.D. with. candidate Jung Woo Yang (POSTECH), senior researcher Hwa Hui Shin (K-MEDI Hub), and Professor Kang-Il Song (PKNU) used mussel-derived adhesives to develop optimized underwater bio-adhesive patches (CUBAP). Using proteins has attracted attention. , his research is published in the journal advanced Materials,

These patches are important in effectively sealing internal wounds, leaks and holes in body organs, aiding healing and tissue regeneration. As research into internal implant devices continues to expand, the need for adhesives that can hold these devices securely in place is increasing.

Biomedical adhesives used in such applications need to maintain strong adhesion underwater while minimizing side effects. The ability to optimize features such as biodegradation time, taking into account the unique biological environment of different organs, is also essential.

Members of Professor Heung Joon Cha’s research team, a pioneer in applying muscle adhesion proteins to medical adhesives, have taken a step forward with the development of CUBAP.

This adhesive is not only excellent at sticking underwater, but is also made from natural materials, ensuring safety and bio-compatibility within the human body. The team has produced customized patches (CUBAP) by combining muscle adhesive proteins with polyacrylic acid and polymethacrylic acid, and these are currently undergoing clinical evaluation to reduce scarring after skin closure .

In its dry state, the patch is non-adhesive, but in the human body or other humid environments, it exhibits strong adhesive properties. Furthermore, researchers can control the degradation time and mechanical stiffness by adjusting the polyacrylic acid and polymethacrylic acid ratio. This enables a customized adhesive system taking into account the diverse structural and biological requirements of different organs.

The research team created three types of customized adhesive patches and applied them in the treatment and transplantation of animals. These patches maintain high adhesion even in highly dynamic organs such as the heart and bladder. They also conducted successful experiments in adjusting the biodegradation time and flexibility during implantation of muscle regeneration electronic devices.

Senior researcher Professor Cha said, “This research paves the way for personalized medicine applications. We plan to scale up and refine the process through subsequent studies, with the goal of effective applications in various biomedical fields “

“Our study confirmed the effectiveness and versatility of the developed bio-adhesive patches. We look forward to developing them into commercial products meeting the demands of the health care sector,” said Hwa Hui Shin, senior researcher at K-Medi Hub. Let’s hope.”

more information:
Zhang Wu Yang et al., A customizable protein bioadhesive patch with water-switchable underwater adhesive, adjustable biodegradability and modified stretchability for healing various internal wounds. advanced Materials (2023). DOI: 10.1002/adma.202310338

Provided by Pohang University of Science and Technology

Citation: Researchers use mussel-derived proteins to develop customized underwater bio-adhesive patches (2024, 13 February) Accessed 13 February 2024 at Retrieved from -proteins-customized-underwater. HTML

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